Journal: Cancers
Article Title: Body Composition and Metabolic Dysfunction Really Matter for the Achievement of Better Outcomes in High-Grade Serous Ovarian Cancer
doi: 10.3390/cancers15041156
Figure Lengend Snippet: Comparative progression-free (PFS; A ) and overall survival (OS; B ) curves, prevalence of different TCGA-OV molecular subtypes ( C ), tumor microenvironment (TME) subtypes (desert [D], fibrotic [F], immune-enriched non-fibrotic [IE], and immune-enriched fibrotic [IE/F]; ( D ), immune subtypes ( E ), tumor mutation burden level (TMB; F ), stemness subtype ( G ), ESTIMATE score ( H ), and prevalence of carcinoma ecotypes (CE, I ) and plasma cell (PC) states (S, J ) according to obesity and lipid metabolism clustering using RNA-seq data from the TCGA-OV cohort.
Article Snippet: Differential expression analyses were carried out using raw counts and the comparative marker selection module (genepattern, Broad Institute, Cambridge, MA, USA [ ]) to calculate the significant differences in gene expression between classes.
Techniques: Mutagenesis, Clinical Proteomics, RNA Sequencing